PentOS OI™ Putty

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100% Allograft DBM Putty
PentOS OI™ Putty is made from 100% human bone without any additional diluent or carriers to diminish its osteoinductive properties.

Description

Description

100% Allograft DBM Putty
PentOS OI™ Putty is made from 100% human bone without any additional diluent or carriers to diminish its osteoinductive properties. EVERY lot used to manufacture PentOS OI™ products is verified to be osteoinductive and histologically demonstrates all five elements of bone formation.

Proven to form bone. Every time. It’s that simple!

Applications
• An osteoinductive base for composite graft preparation.
• Bone defects and sites requiring a high level of osteoinduction.

Overview

Overview

All PentOS OI™ allografts must demonstrate all five elements of bone formation before they are released for use.  

1. New bone
New bone is the final step in the maturation of the product.

2. Bone marrow
The presence of bone marrow indicates the ability of the product to differentiate into osteoblasts, chondrocytes, cartilage and new bone.

3. Osteocytes
Osteocytes are derived from osteoblasts, or bone forming cells, and are essentially osteoblasts surrounded by the products they secreted.

4. Cartilage
Cartilage is replaced by bone during ossification in the higher vertebrates. It is indicative that the bone formation is forthcoming.

5. Chondrocyte
A Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells.

Post sterilization in-vivo testing on each lot must demonstrate the presence of new bone, bone marrow, osteocytes, cartilage and chondrocytes within 28 days in an athymic rat model otherwise we don’t call it PentOS OI™. 
In-vitro tests of PentOS OI™ have demonstrated native levels of BMP-2 up to 19 times the native levels in the control.

Features

Features

Features & Benefits
• Verified to be osteoinductive
• Osteoconductive
• Excellent handling characteristics
• Resists irrigation
• Sterilized using low-dose gamma irradiation
• Ready to use
• Stored at room temperature

Availability

Availability

PentOS OI Putty is available in syringe of:
· 0.5 cc
· 1.0 cc
· 2.5 cc
· 5.0 cc

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