Accell® contains BMPs and growth factors with DBM to accelerate the body’s healing response. In nature, these elements work together as part of the natural bone formation process: Growth factors (TGF-ß and IGF-1) recruit stem cells to the surgical site. TGF-ß also stimulates the stem cells to replicate, creating the cellular foundation for new bone.
VEG-F stimulates the formation of new blood vessels, increasing blood flow to the site. BMP-2, BMP-4 and BMP-7 transform stem cells into osteoblasts (bone forming cells). FGF and PDGF promote replication of stem cells and osteoblasts. As the osteoblasts form, they organize themselves to create new bone.
Accell® Connexus combines the virtues of ABM and DBM in one powerful product
Accell® Bone Matrix's increased surface area provides access tos natural bone proteins. Natural bone protein content of ABM and particulate DBM was measured in vitro over time using an Enzyme Linked Immunosorbent Assay (ELISA). The results are shown graphically and indicate that bone protein was detectable in a saline solution containing ABM at earlier time points compared to that of particulate DBM. The higher surface area and more open pore structure of ABM provides accessibility to the bone protein, without the need to be broken down. This analysis shows that while ABM provided early accessibility of natural bone protein, particulate DBM provides for accessibility of natural bone protein at later time points.