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Dynamatrix™, The new dynamic for tissue remodeling

DynaMatrix is a biological extracellular matrix

DynaMatrix is a biological extracellular matrix (ECM) that contains two of the three essential biological components required for healing:

· Matrix scaffold
· Signals, which include growth factors and ECM cell receptor-mediated binding sites

Once implanted, these components work together to stimulate the recruitment of the body’s cells, which in turn become the third component critical to healing. Derived from porcine small intestinal submucosa (SIS), DynaMatrix is a natural biomaterial that does not contain cells but does maintain a three-dimensional structure, which is important for tissue remodeling.

That is why this is the new dynamic for tissue remodeling.

See our membranes comparison chart page

DynaMatrix on Discovery Channel's Health Heroes, view video.

DynaMatrix features

DynaMatrix is available in three sizes: 15x20, 20x30 and 30x40 mm

Superior handling and ease of use

          • Combines remarkable strength and flexible handling.

          • Can be cut, rolled or folded to accommodate defect site requirements.

          • Pliable enough to facilitate handling, yet strong enough to be sutured or tacked.

          Significant Remodeling and Healing Properties

          • Supports safe and effective repair by not dissolving in the site or causing chronic inflammation.

          • The biologic material guides the patient’s soft tissue to form organized tissue, not scar tissue. This tissue becomes functional, without a foreign substance left behind.

          • Not synthetically nor chemically cross-linked.

Available in three sizes: 15x20, 20x30 and 30x40 mm

Why does ECM matter ?

DynaMatrix is Pliable enough to facilitate handling, yet strong enough to be sutured or tacked.Simply put, it is the ECM that makes the remodeling happen.

DynaMatrix is comprised of essential components needed for tissue remodeling except for the cells, making it more than just collagen. As an extracellular matrix, it retains the natural composition of matrix molecules such as collagen, glycosaminoglycans, proteoglycans and glycoproteins, which are known to have important roles in tissue repair and remodeling.1-6
Each ECM protein interacts with cells and with each other to form a highly complex communication network where cells are signalled to remodel.

Major Protein components of ECM:

  • Fibrillar collagens
    Basis for tissue strength and stability

  • Non-fibrillar collagens
    Provide mesh-like structure that gives microvessels their stability

  • Glycoproteins
    Main non-collagenous support structure that possesses attachment sites for cells, in particular; small blood vessels

  • Proteoglycans
    Attach to outer surface of cells and act as binding sites for growth factors

  • Glycosaminoglycans (GAGs)
    Heparin and hyaluronic acid are two important GAGs. Heparin regulates the function of several growth factors and assists in angiogenesis following injury. Hyaluronic acid is thought to help regulate matrix density and inhibit scar formation during healing.

  • Growth factors
    Small protein structures that control cell growth, differentiation and ECM deposition by the cells. Growth factors initiate wound healing, regulate blood vessel formation and maintain tissue homeostasis.

Sources:
1. Hodde JP, Badylak SF, Brightman AO, et al. “Glycosaminoglycan content of small intestinal submucosa: A bioscaffold for tissue replacement.” Tissue Engineering, 1996; 2: 209-217.
2. McPhersonTB, Badylak SF. “Characterization of fibronectin derived from porcine small intestinal submucosa.” Tissue Engineering, 1998; 4: 75-83.
3. Voytik-Harbin SL, Brightman AO, Kraine MR, et al. “Identification of extractable growth factors from small intestinal submucosa.” Journal of Cellular Biochemistry, 1997; 67: 478-491.
4. Hodde JP, Hiles MC, “Bioactive FGF-2 in sterilized extracellular matrix.” Wounds, 2001; 13: 195-201.
5. Hodde JP, Ernst DMJ, Hiles MC. “An investigation of the long-term bioactivity of endogenous growth factor in oasis wound matrix.” JournalWound Care, 2005; 14: 23-25.
6. McDevitt CA,Wildey GM, Cutrone RM. “Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucosa.” Journal of Biomedical Materials Research, 2003; 67A: 637-640.

DynaMatrix is an extracellular matrix derived from Small Intestinal Submucosa (SIS)