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Dynamatrix™, The new dynamic for tissue remodeling
DynaMatrix is a biological extracellular matrix (ECM) that contains two of the three essential biological components required for healing:
· Matrix scaffold
· Signals, which include growth factors and ECM cell receptor-mediated binding sites
Once implanted, these components work together to stimulate the recruitment of the body’s cells, which in turn become the third component critical to healing. Derived from porcine small intestinal submucosa (SIS), DynaMatrix is a natural biomaterial that does not contain cells but does maintain a three-dimensional structure, which is important for tissue remodeling.
That is why this is the new dynamic for tissue remodeling.
Superior handling and ease of use
Combines remarkable strength and flexible handling.
Can be cut, rolled or folded to accommodate defect site requirements.
Pliable enough to facilitate handling, yet strong enough to be sutured or tacked.
Supports safe and effective repair by not dissolving in the site or causing chronic inflammation.
The biologic material guides the patient’s soft tissue to form organized tissue, not scar tissue. This tissue becomes functional, without a foreign substance left behind.
Not synthetically nor chemically cross-linked.
Significant Remodeling and Healing Properties
Available in three sizes: 15x20, 20x30 and 30x40 mm
Why does ECM matter ?
Simply put, it is the ECM that makes the remodeling happen.
DynaMatrix is comprised of essential components needed for tissue remodeling except for the cells, making it more than just collagen. As an extracellular matrix, it retains the natural composition of matrix molecules such as collagen, glycosaminoglycans, proteoglycans and glycoproteins, which are known to have important roles in tissue repair and remodeling.1-6
Each ECM protein interacts with cells and with each other to form a highly complex communication network where cells are signalled to remodel.
Major Protein components of ECM:
Basis for tissue strength and stability
Provide mesh-like structure that gives microvessels their stability
Main non-collagenous support structure that possesses attachment sites for cells, in particular; small blood vessels
Attach to outer surface of cells and act as binding sites for growth factors
Heparin and hyaluronic acid are two important GAGs. Heparin regulates the function of several growth factors and assists in angiogenesis following injury. Hyaluronic acid is thought to help regulate matrix density and inhibit scar formation during healing.
Small protein structures that control cell growth, differentiation and ECM deposition by the cells. Growth factors initiate wound healing, regulate blood vessel formation and maintain tissue homeostasis.
1. Hodde JP, Badylak SF, Brightman AO, et al. “Glycosaminoglycan content of small intestinal submucosa: A bioscaffold for tissue replacement.” Tissue Engineering, 1996; 2: 209-217.
2. McPhersonTB, Badylak SF. “Characterization of fibronectin derived from porcine small intestinal submucosa.” Tissue Engineering, 1998; 4: 75-83.
3. Voytik-Harbin SL, Brightman AO, Kraine MR, et al. “Identification of extractable growth factors from small intestinal submucosa.” Journal of Cellular Biochemistry, 1997; 67: 478-491.
4. Hodde JP, Hiles MC, “Bioactive FGF-2 in sterilized extracellular matrix.” Wounds, 2001; 13: 195-201.
5. Hodde JP, Ernst DMJ, Hiles MC. “An investigation of the long-term bioactivity of endogenous growth factor in oasis wound matrix.” JournalWound Care, 2005; 14: 23-25.
6. McDevitt CA,Wildey GM, Cutrone RM. “Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucosa.” Journal of Biomedical Materials Research, 2003; 67A: 637-640.
DynaMatrix is an extracellular matrix derived from Small Intestinal Submucosa (SIS)