Accell® Advanced Bone Grafting Product
Natural Healing
Accell features a concentrated form of the same BMPs and growth factors that the human body produces to form new bone—with nearly five times more BMPs than DBM alone. Because Accell contains only human bone and Reverse Phase Medium, a proprietary carrier, it eliminates the potential for reaction to non-human collagen.
Easy Handling
Its proprietary Reverse Phase Medium makes Accell moldable and easy to pack into any shape defect. It requires no special handling, storage, thawing, mixing or setting. Accell thickens at body temperature to hold the graft in place and resists irrigation to allow for better graft containment.
Proven Results
Accell contains BMPs and growth factors with DBM to accelerate the body’s healing response. In nature, these elements work together as part of the natural bone formation process:
Growth factors (TGF-ß and IGF-1) recruit stem cells to the surgical site. TGF-ß also stimulates the stem cells to replicate, creating the cellular foundation for new bone.
VEG-F stimulates the formation of new blood vessels, increasing blood flow to the site.
BMP-2, BMP-4 and BMP-7 transform stem cells into osteoblasts (bone forming cells).
FGF and PDGF promote replication of stem cells and osteoblasts. As the osteoblasts form, they organize themselves to create new bone.
Accell vs. First Generation DBM after 4 weeks

Skeletally mature sheep model.
Cylindrical 5 mm metatarsal defect created in tibial diaphysis.
Results after 4 week

Control - Empty
Minimal bone regeneration observed at 4 weeks. Healing limited to area adjacent to host bone.
1st Generation DBM
Bone regeneration occurs throughout the defect, caused by the presence of osteoinductive DBM particles. The inert carrier has been metabolized.
(DynaGraft II®)
Accell
Significantly more bone formation is evident immediately adjacent to the bone repair surfaces and within the interior of the defect. We believe this occurs because of the immediate access to the BMPs in the Accell products.
(Accell 100™)

 

Accell is available in
0.5, 1, 2.5 and 5 cc
prefilled syringes.

Accell Bone Matrix's increased surface area provides access tos natural bone proteins. Natural bone protein content of ABM and particulate DBM was measured in vitro over time using an Enzyme Linked Immunosorbent Assay (ELISA). The results are shown graphically and indicate that bone protein was detectable in a saline solution containing ABM at earlier time points compared to that of particulate DBM. The higher surface area and more open pore structure of ABM provides accessibility to the bone protein, without the need to be broken down. This analysis shows that while ABM provided early accessibility of natural bone protein, particulate DBM provides for accessibility of natural bone protein at later time points.