Accell Connexus highly osteoinductive Demineralized Bone Matrix in a Reverse Phase Medium, orthopedics

Accell 100
Accell Connexus
DynaGraft II
MBCP
Cancellous Bone

Osteodisc for orthopedics

Accell Connexus®

Incorporates

Accell Technology
Isotis OrhoBiologics Processed DBM
30% Poloxamer Reverse Phase Medium Carrier

Benefits

Validated Osteoinductive Potential
Poloxamer Reverse Phase Medium
- Thickens at body temperature
- Resists irrigation allowing for better graft containment
- Is inert, biocompatible and safe
Moldable and easy to pack into virtually any size or shape defect
Ready to use

Lot Division

Each donor lot of DBM is divided in two. Half is reserved for the final formulation.

Solubilization

The remaining half undergoes the Accell process which results in flowable carrier with osteoinductive potential.

Final Formulation

The flowable carrier is then combined with the DBM particles consisting of two components with osteoinductive potential.

E-Beam Sterilization

IsoTis OrthoBiologics terminally sterilizes every lot of Accell product with a low-dose electron beam, a process that has been demonstrated to preserve the osteoinductive potential of bone growth factors.

Skeletally mature sheep model.
Cylindrical 5 mm metatarsal defect created in tibial diaphysis.
Results after 4 weeks.


Control - Empty Minimal bone regeneration observed at 4 weeks. Healing limited to area adjacent to host bone.	1st Generation DBM Bone regeneration occurs throughout the defect, caused by the presence of osteoinductive DBM particles. The inert carrier has been metabolized. (DynaGraft II®)	Accell Significantly more bone formation is evident immediately adjacent to the bone repair surfaces and within the interior of the defect. We believe this occurs because of the immediate access to the BMPs in the Accell products. (Accell 100™)


• Accell Brochure • Patient Brochure • In Vivo Osteoinductivity...

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